Skyler and Walter have a teenage son, Walter White Jr., and an infant daughter, Holly White. Skyler cares for Walter very much, but their marriage becomes increasingly strained due to his unexplained absences and bizarre behavior, ultimately leading to their separation.

Later, once Walter reveals his involvement in the meth business, she initially seeks a divorce but ultimately ends up aiding him in laundering his illicit funds. At Skyler's behest, the Whites eventually procure the A1A Car Wash that Walter once had to work at. As Walter slowly becomes more of a "hardened criminal," she becomes increasingly frightened for her and her children's safety, attempting to get Walt Jr. and Holly as far away from their father as possible.

Walter Jr. is Walter and Skyler White's seventeen year-old son, and the older brother of Holly White. He attends J. P. Wynne High School, where his father used to work as a high school chemistry teacher.

Walter Jr. was born with cerebral palsy, manifested in speech difficulties and impaired motor control, for which he uses crutches. He grows apart from Walt due to his father's absences and bizarre behavior, being taught to drive, for the most part, by his friends and going through a phase in which he preferred to be called "Flynn."

Henry R. "Hank" Schrader is the husband of Marie Schrader (the sister of Skyler White) and Assistant Special Agent in Charge (ASAC) of the Albuquerque office of the Drug Enforcement Administration. A high-energy and boisterous man, Hank is Walter White's brother-in-law.

Although he is a highly competent agent and genuinely cared about Marie, Walter, Skyler White and Walter White Jr., his loud ways insulated him from the danger he faced daily.

Marie Schrader (née Lambert) is Skyler White's sister, the wife of DEA agent Hank Schrader, and the sister-in-law of Walter White. Marie is close with her sister, though her tendency to pry invariably irritates Skyler. Marie works a radiologic technologist at Kleinman Radiology Center, a medical scanning and X-ray office. She and Hank together had no children.

Marie becomes a major source of comfort and support to her husband, who proves to be more emotionally fragile than he lets on. After Hank is shot and nearly killed by The Cousins, Marie arranges, with Walt and Skyler's help, for Hank to undergo an aggressive physical therapy program that is not covered by their insurance. Despite a rough patch in their relationship as Hank recovers, their marriage becomes loving again when Hank begins making progress with the Heisenberg case and she becomes stable enough to care emotionally for her family members. When Walt and Skyler begin to visibly have marriage problems, she volunteers to house the kids for a couple of days while they work things out. Marie loves the color purple, and nearly all her household and clothing items are various shades of purple.

Saul was born in Cicero, Illinois as James Morgan "Jimmy" McGill. His older brother Chuck became a successful lawyer as one of the partners at an Albuquerque law firm, Hamlin, Hamlin & McGill. Jimmy became a scam artist in Cicero and soon gained the nickname "Slippin' Jimmy" for staging "slip and fall" accidents to make quick cash. Jimmy runs into trouble with the police and Chuck returns to help but requires that Jimmy join him in Albuquerque and work a legitimate job in HHM's mail room. Jimmy befriends Kim Wexler, an HHM employee who is attending law school. Inspired by her success, Jimmy completes his college degree and attends a correspondence law school. He passes the bar exam and hopes to be hired at HHM, but at Chuck's secret instigation, senior partner Howard Hamlin denies Jimmy the opportunity. Jimmy then starts a solo practice in the utility room of a Vietnamese nail salon. He takes whatever cases he can get, including low paid public defender work. Jimmy frequently gets into altercations with the stoic Mike Ehrmantraut, a former police officer working as the clerk at the courthouse's parking lot.

Michael "Mike" Ehrmantraut was a former corrupt police officer who, after being forced to leave the police department, used his connections in the criminal underworld to eventually become Gustavo Fring's right-hand man. Despite his responsibilities as the second-in-command of the mob, he occasionally carried out favours for his lawyer and old associate Saul Goodman as a private investigator, cleaner, and fixer, out of loyalty to Saul (they had known each other for six years). Prior to his involvement in Gus's operation, Mike worked as parking ticket booth operator at a local courthouse, where he met Saul, then known as Jimmy McGill.

Lydia was Gus Fring's methylamine supplier. After Gus' death, Lydia asks Mike to eliminate any loose ends that might connect her to the world of organized crime. When Mike refuses, she hires someone else to kill Mike and Gus' other associates. Mike outmaneuvers the hitman, and nearly kills Lydia for her deception. At the last minute, he offers clemency on the condition that she supplies methylamine to Walt's new meth operation.

Todd was originally an employee of Vamonos Pest. He and his crew were hired by Mike Ehrmantraut to help in a methamphetamine operation led by Walter White and Jesse Pinkman. The pest control crew was ordered not to talk to Walt and Jesse at any time: they should only set up a house for the poison bombing, set up the secret mobile meth lab inside and clear space for the two cooks. Before Walt and Jesse's first cook, Todd informed the duo of a nanny-cam in the living room of the house.

Gustavo "Gus" Fring is a Chilean-born Albuquerque restaurateur, mob boss, business magnate, and philanthropist. He is the respected proprietor of Los Pollos Hermanos, a highly successful restaurant chain. However, despite outward appearances, Gus is a major drug kingpin initially affiliated with the Mexican Juárez Cartel, secretly using his restaurant as a legitimate cover for methamphetamine distribution throughout the American southwest. Like Walter White, Gus is a criminal who "hid in plain sight", using his anti-drug philanthropy to conceal his true nature and build his illicit drug empire step by step.

Steven "Steve" Gomez was Hank Schrader's partner at the Albuquerque DEA office, as well as his close friend.

A mellow, by-the-book foil to Hank's over the top, strikeforce flair, "Gomie" reluctantly developed leads with Hank on the investigation into Heisenberg and the notorious "blue sky" meth.

Being of a Latino background, he has a little more knowledge about the inner workings of Mexican gangs than Hank. The relationship between the two partners was based on mutual respect, but also plenty of decent ribbing about everything including bad breath or the finer points of various local ethnicities. When Hank describes Tuco Salamanca as Gomie's homie, his partner hits him right back: "Tuco wasn't my homie anymore than Charlie Manson was yours." He had a wife named Blanca Gomez.

Badger, as a condition of his probation stipulating that he find and maintain employment, is working as a walking billboard, wearing a full-body dollar bill costume for a realty company. Despite is probation, he continues to use drugs recreationally. When he runs into Jesse, the two teamed up briefly to cook meth by using the money from Badger's job to buy pseudophedrine.

Skinny Pete is one of Jesse's closest friends. Early on, Skinny hooks Jesse up with Tuco Salamanca, a high-level drug distributor he met in jail. The meeting goes poorly: Tuco steals Jesse's meth and beats him up.

After Hank Schrader kills Tuco in a shootout, Walt and Jesse begin distributing meth on their own. Jesse, in charge of the street operation, enlists Skinny Pete and two other friends, Combo and Badger, as dealers. A couple of junkies steal meth from Skinny, but his reputation stays intact thanks to a rumor that Jesse retaliated by crushing one junkie's head with an ATM.

Tuco is known for his erratic personality and propensity for extreme violence, making him one of the most dangerous drug dealers in New Mexico. He is shown to be capable of killing people close to him without showing remorse if they do something he finds disrespectful. However, Tuco shows signs of being extremely loyal to the people he truly trusts. His family is tied to the Juárez Cartel, as his uncle Don Hector Salamanca was one of the highest ranking members of the cartel. Tuco's cousins were also hit-men for the cartel. Tuco was trained by Don Hector in the art of selling and distributing meth. He groomed Tuco to eventually take his place in the organization when Hector was unable to continue. It is revealed that Hector treated Tuco as a son, showing how strong the bond between uncle and nephew was.

Don Hector Salamanca, also known as Tio, was a drug runner and the former right hand man and enforcer of Don Eladio. Hector was a high-ranking member of the Juárez Cartel, the patriarch of the Salamanca family, and was feared among most in the South. He was the son of Abuelita, the uncle of Tuco, Marco, Leonel and Lalo Salamanca, as well as the grandfather of Joaquin Salamanca.

Leonel and Marco are the nephews of Don Hector Salamanca, who taught them early on that family is everything - proving so by nearly drowning one until the other fought back against him. They were also the grandsons of Abuelita and they had three cousins connected to criminal actions: Tuco, Lalo and Joaquin Salamanca. They were typically dressed in well-cut sharkskin suits and distinctive cowboy boots tipped with silver skulls, and appeared to worship the Mexican deity of death Santa Muerte, making offerings to a shrine when undertaking an assassination.

Ted is a divorcee with twin daughters. He took over his family's business at some point during his adult years and developed a close bond with his employees. Ted harbored feelings for Skyler White during her brief stint at the company when she was young, and eventually made a drunken pass at her (for which he later apologized profusely). Skyler left the company soon afterward, but Ted's feelings for her remained intact for years.

As Beneke Fabricators began a financial downward decline, Ted resorted to committing major fraud in order to keep the company alive, by cooking the books.

Jane Margolis is a tattoo artist and Jesse Pinkman's neighbor, landlord and girlfriend. She was also a recovering drug addict. Although she first appeared aloof, she and Jesse soon become a couple, a fact she hid from her father, Donald Margolis, the owner of the building in which she and Jesse lived.

Gus Fring hired Walter after Gale praised a sample of Walt's blue meth as the purest he'd ever seen. Following this point, Gale became Walt's lab assistant.

Gale holds an MS degree in organic chemistry and is a specialist in X-ray crystallography. He described his political views as libertarian, and had an open-minded attitude regarding meth. A self-described "nerd," Gale was single, vegan, apparently quite cultured, and was perhaps near to being an intellectual equal of Walt. As a side project, he was working on a process for brewing a superior cup of coffee, and impresses Walt with his results.